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Stephan van Gils  (University of Twente): The Cross-Scale Effects of Neural Interactions during Human Neocortical Seizure Activity

iCal fájl letöltése
Csütörtök, 30. Augusztus 2018, 10:00 - 12:00
Abstract. Under certain circumstances, small numbers of neurons within the network may impose widespread effects on network dynamics. In order to unravel this relationship between neuronal functioning and large network dynamics, we analyzed eight multi-scale recordings of spontaneous seizures from four patients with epilepsy. During seizures, multi-unit spike activity organizes into a sub-mm-sized wavefront, and this activity correlates significantly with low frequency rhythms across a 10-cm-sized cortical network. Notably, this correlation effect is specific to the ictal wavefront and is not present interictally or from action potential activity outside the wavefront territory. To examine the multiscale interactions, we created a model using a multiscale, nonlinear system and demonstrated a dual role for feedforward inhibition in seizures. While inhibition at the wavefront fails and allows for seizure propagation, feedforward inhibition of the surrounding cm-scale networks is activated via long-range excitatory connections. Bifurcation analysis revealed that distinct dynamical pathways for seizure termination exist. Using our model to study multiscale mechanisms in ongoing seizure activity, we found that the mesoscopic, local wavefront acts as the forcing term of the ictal process while the macroscopic, cm-sized, network responds with oscillatory seizure activity.
Hely : Bolyai Intézet, I. emelet, Riesz terem, Aradi Vértanúk tere 1., Szeged


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